Natural products targeting clinically relevant enzymes / (Record no. 79681)
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| 000 -LEADER | |
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| fixed length control field | 05968cam a2200649Ii 4500 |
| 001 - CONTROL NUMBER | |
| control field | on1002418559 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20201009115433.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu|||unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170901s2017 gw a ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | N$T |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | N$T |
| Modifying agency | IDEBK |
| -- | EBLCP |
| -- | NLE |
| -- | N$T |
| -- | DG1 |
| -- | OCLCF |
| -- | RECBK |
| -- | MERER |
| -- | YDX |
| -- | UAB |
| 019 ## - | |
| -- | 1002830648 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527805938 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3527805931 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527805921 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3527805923 |
| Qualifying information | (electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9783527342051 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 3527342052 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)1002418559 |
| Canceled/invalid control number | (OCoLC)1002830648 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QP601 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED |
| Subject category code subdivision | 075000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI |
| Subject category code subdivision | 036000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 612.0151 |
| Edition number | 23 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | MAIN |
| 245 00 - TITLE STATEMENT | |
| Title | Natural products targeting clinically relevant enzymes / |
| Statement of responsibility, etc. | edited by Paula B. Andrade, Patrícia Valentão, David M. Pereira. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Weinheim, Germany : |
| Name of producer, publisher, distributor, manufacturer | Wiley-VCH, |
| Date of production, publication, distribution, manufacture, or copyright notice | [2017] |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | ©2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource : |
| Other physical details | illustrations |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Includes bibliographical references. |
| 588 0# - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Online resource; title from PDF title page (EBSCO, viewed September 11, 2017). |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 2.3 Proteasome Inhibitors2.3.1 Carmaphycins; 2.4 Protease Enzymes; 2.4.1 Serine Protease Inhibitors; 2.4.2 Falcipain Inhibitors; 2.4.2.1 Gallinamide A; 2.4.3 Cathepsin Inhibitors; 2.4.4 b-Secretase 1 (BACE1) Inhibitors; 2.4.4.1 Tasiamide B; 2.5 Protein Kinase C Modulators; 2.5.1 Aplysiatoxins; 2.6 Interference of the Actin and Microtubule Filaments; 2.6.1 Dolastatins 10/15; 2.6.2 Bisebromoamide; 2.7 Sec61 Protein Translocation Channel Inhibitors; 2.7.1 Apratoxin A; 2.8 Prohibitin Inhibitors; 2.8.1 Aurilide; 2.9 Sodium Channels Modulators; 2.10 Conclusions; References |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 4.3 Marine Molecules as PLA2 Inhibitors4.3.1 Sponge-Derived Metabolites; 4.3.2 Metabolites from Other Organisms; 4.4 Conclusion; References; Chapter 5 b-Secretase (BACE1) Inhibitors from Natural Products; 5.1 Introduction; 5.2 Flavonoids; 5.2.1 Flavones, Flavonols and Flavone Glycosides; 5.2.2 Dihydroflavonoids; 5.2.3 Biflavonoids; 5.2.4 Chalcones; 5.2.5 Isoflavonoids; 5.2.6 Catechins; 5.2.7 Xanthones; 5.3 Chromones; 5.4 Phenolic Acids and Tannins; 5.4.1 Phenol Acids; 5.4.2 Tannins; 5.4.3 Simple Phenol Derivatives and Polyphenols; 5.5 Stilbenes and Derivatives; 5.6 Coumarins |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 5.7 Benzoquinones and Anthraquinones5.8 Alkaloids; 5.9 Terpenes; 5.10 Lignans; 5.11 Fatty Acid; 5.12 Saccharides, Peptides and Amino Acid Derivatives; 5.13 BACE1 Inhibitory Active Extracts of Natural Products; 5.14 Bioassays for the Discovery of BACE1 Inhibitors; 5.15 Prospective; Acknowledgements; References; Chapter 6 Hypoglycaemic Effects of Plants Food Constituents via Inhibition of Carbohydrate-Hydrolysing Enzymes: From Chemistry to Future Applications; 6.1 Introduction; 6.2 a-Amylase; 6.3 a-Glucosidase; 6.4 Hypoglycaemic Natural Compounds; 6.4.1 Flavonoids; 6.4.2 Phenolic Acids |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Cover; Title Page; Copyright; Contents; List of Contributors; Chapter 1 Natural Products as Enzyme Inhibitors; 1.1 Why Are Natural Products Good Enzyme Inhibitors?; 1.2 Drawbacks of Natural Products; 1.3 The Future of Natural Products Drug Discovery; 1.3.1 New Sources and New Production Methods; 1.3.2 New Strategies for Delivery; 1.3.3 New Targets?/Drug Repurposing; 1.4 Conclusion; References; Chapter 2 Molecular Targets of Clinically Relevant Natural Products from Filamentous Marine Cyanobacteria; 2.1 Introduction; 2.2 Histone Deacetylase Inhibitors; 2.2.1 Largazole; 2.2.2 Santacruzamate A |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Chapter 3 Natural Angiotensin Converting Enzyme (ACE) Inhibitors with Antihypertensive Properties3.1 Introduction; 3.2 Mechanisms of Blood Pressure Regulation; 3.2.1 Renin-Angiotensin-Aldosterone System; 3.3 The Treatment of Hypertension; 3.3.1 Angiotensin Converting Enzyme Inhibitors; 3.4 Natural Products as Angiotensin Converting Enzyme Inhibitors; 3.4.1 Polyphenols; 3.4.2 Protein Derived Peptides; 3.5 Conclusions; References; Chapter 4 Phospholipase A2 Inhibitors of Marine Origin; 4.1 Relevance of Marine Organisms; 4.2 Inflammation; 4.2.1 Phospholipase A2 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Enzymes |
| General subdivision | Effect of drugs on. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Natural products |
| General subdivision | Therapeutic use. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Bioactive compounds. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | MEDICAL / Physiology. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SCIENCE / Life Sciences / Human Anatomy & Physiology. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Bioactive compounds. |
| Source of heading or term | fast |
| Authority record control number or standard number | (OCoLC)fst00831933 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Enzymes |
| General subdivision | Effect of drugs on. |
| Source of heading or term | fast |
| Authority record control number or standard number | (OCoLC)fst00913612 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Natural products |
| General subdivision | Therapeutic use. |
| Source of heading or term | fast |
| Authority record control number or standard number | (OCoLC)fst01034400 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 655 #0 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Andrade, Paula B., |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Valentão, Patrícia, |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pereira, David M., |
| Relator term | editor. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Qualifying information | Original |
| International Standard Book Number | 9783527342051 |
| -- | 3527342052 |
| Record control number | (OCoLC)989967773 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1002/9783527805921">https://doi.org/10.1002/9783527805921</a> |
| Public note | Wiley Online Library |
| 994 ## - | |
| -- | 92 |
| -- | DG1 |
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