Organometallic chemistry in industry (Record no. 80260)
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| fixed length control field | 06697cam a2200481Ia 4500 |
| 001 - CONTROL NUMBER | |
| control field | on1140787329 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20201009115524.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr un|---aucuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200215s2020 gw ob 001 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EBLCP |
| Language of cataloging | eng |
| Transcribing agency | EBLCP |
| Modifying agency | DG1 |
| -- | OCLCF |
| -- | RECBK |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527819201 |
| Qualifying information | (electronic bk. : oBook) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3527819207 |
| Qualifying information | (electronic bk. : oBook) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783527819195 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3527819193 |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Canceled/invalid ISBN | 9783527345175 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)1140787329 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QD411 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 661/.895 |
| Edition number | 23 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | MAIN |
| 245 00 - TITLE STATEMENT | |
| Title | Organometallic chemistry in industry |
| Medium | [electronic resource] : |
| Remainder of title | a practical approach / |
| Statement of responsibility, etc. | edited by Thomas J. Colacot, Carin C.C. Johansson Seechurn. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Weinheim : |
| Name of publisher, distributor, etc. | Wiley-VCH, |
| Date of publication, distribution, etc. | 2020. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (338 p.) |
| 500 ## - GENERAL NOTE | |
| General note | Description based upon print version of record. |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Cover -- Title Page -- Copyright -- Contents -- Foreword -- Preface -- Chapter 1 Industrial Milestones in Organometallic Chemistry -- 1.1 Definition of Organometallic and Metal-Organic Compounds -- 1.1.1 Applications and Key Reactivity -- 1.1.1.1 Electronic Applications -- 1.1.1.2 Polymers -- 1.1.1.3 Organic Synthesis -- 1.2 Industrial Process Considerations -- 1.3 Brief Notes on the Historical Development of Organometallic Chemistry for Organic Synthesis Applications Pertaining to the Contents of this Book -- 1.3.1 Synthesis of Stoichiometric Organometallic Reagents |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 1.3.1.1 Conventional Batch Synthesis -- 1.3.1.2 Organometallics in Flow -- 1.3.2 Cross-coupling Reactions -- 1.3.2.1 C-HBond Activation -- 1.3.2.2 Carbonylation -- 1.3.2.3 Catalysis in Water - Micellar Catalysis -- 1.3.3 Hydrogenation Reactions -- 1.3.4 Olefin Formation Reactions -- 1.3.4.1 Wittig Reaction -- 1.3.4.2 Metathesis Reactions -- 1.3.4.3 Dehydrative Decarbonylation -- 1.3.4.4 Olefins as Starting Materials -- 1.3.5 Poly- or Oligomerization Processes -- 1.3.6 Photoredox Catalysis for Organic Synthesis -- 1.4 Conclusion and Outlook -- Biography -- References |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Chapter 2 Design, Development, and Execution of a Continuous-flow-Enabled API Manufacturing Route -- 2.1 Continuous-flow-Enabled Synthetic Strategy -- 2.2 Design and Scale-up of Chan-Lam Coupling -- 2.2.1 Development of Homogeneous Conditions -- 2.2.2 Application of a Platform Technology to Aerobic Oxidation -- 2.2.3 Optimization of Reaction and Workup Parameters -- 2.2.4 Safety Considerations for Aerobic Oxidation on Scale -- 2.2.5 Continuous Scale-up and Manufacturing -- 2.3 Design and Scale-up of a Buchwald-Hartwig Cross-coupling -- 2.3.1 Initial Screening |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 2.3.2 Synthesis and Isolation of Pd(dba)DPEPhos Precatalyst -- 2.3.3 Workup Procedure, Metal Removal, and Crystallization -- 2.3.4 Scale-up and Manufacturing -- 2.4 Impurity Control -- 2.4.1 Solubility and Impurity Spiking Studies -- 2.5 Conclusions -- Biography -- References -- Chapter 3 Continuous Manufacturing as an Enabling Technology for Low-Temperature Organometallic Chemistry -- 3.1 Introduction -- 3.2 Organo-Li and Mg Processes in Flow Mode -- 3.2.1 Technological Advantages of Flow Technology Compared to Traditional Batch Operation -- 3.2.2 Temperature Profile of Continuous Flow Reactions |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3.2.3 Flash Chemistry: Functional Group Tolerance -- 3.2.4 Flash Chemistry: Selectivity -- 3.2.5 Flash Chemistry: Stoichiometry and Chemoselectivity -- 3.3 Continuous Flow Technology -- 3.3.1 Clogging as a Major Hurdle in Flow Chemistry -- 3.3.2 Start-up and Shutdown Operation -- 3.3.3 Material of Construction -- 3.3.4 Safety Concept and Emergency Strategies -- 3.4 Development of a Flow Process -- 3.4.1 Screening Phase: Feasibility Study -- 3.4.2 Process Development Phase: Extended Evaluations Including Technical Feasibility -- 3.5 Literature Examples: Flow Processes on Multi 100 g Scale |
| 500 ## - GENERAL NOTE | |
| General note | 3.5.1 Manufacture of Verubecestat (MK-8931) |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Includes bibliographical references and index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Organometallic chemistry. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SCIENCE / Chemistry / Organic. |
| Source of heading or term | bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Organometallic chemistry. |
| Source of heading or term | fast |
| Authority record control number or standard number | (OCoLC)fst01047969 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Colacot, Thomas. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Seechurn, Carin C. C. Johansson. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Grubbs, Robert H. |
| Title | Organometallic Chemistry in Industry : A Practical Approach |
| Place, publisher, and date of publication | Newark : John Wiley & Sons, Incorporated,c2020 |
| International Standard Book Number | 9783527345175 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1002/9783527819201">https://doi.org/10.1002/9783527819201</a> |
| Public note | Wiley Online Library |
| 994 ## - | |
| -- | 92 |
| -- | DG1 |
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