Natural products targeting clinically relevant enzymes /
edited by Paula B. Andrade, Patrícia Valentão, David M. Pereira.
- 1 online resource : illustrations
Includes bibliographical references.
2.3 Proteasome Inhibitors2.3.1 Carmaphycins; 2.4 Protease Enzymes; 2.4.1 Serine Protease Inhibitors; 2.4.2 Falcipain Inhibitors; 2.4.2.1 Gallinamide A; 2.4.3 Cathepsin Inhibitors; 2.4.4 b-Secretase 1 (BACE1) Inhibitors; 2.4.4.1 Tasiamide B; 2.5 Protein Kinase C Modulators; 2.5.1 Aplysiatoxins; 2.6 Interference of the Actin and Microtubule Filaments; 2.6.1 Dolastatins 10/15; 2.6.2 Bisebromoamide; 2.7 Sec61 Protein Translocation Channel Inhibitors; 2.7.1 Apratoxin A; 2.8 Prohibitin Inhibitors; 2.8.1 Aurilide; 2.9 Sodium Channels Modulators; 2.10 Conclusions; References 4.3 Marine Molecules as PLA2 Inhibitors4.3.1 Sponge-Derived Metabolites; 4.3.2 Metabolites from Other Organisms; 4.4 Conclusion; References; Chapter 5 b-Secretase (BACE1) Inhibitors from Natural Products; 5.1 Introduction; 5.2 Flavonoids; 5.2.1 Flavones, Flavonols and Flavone Glycosides; 5.2.2 Dihydroflavonoids; 5.2.3 Biflavonoids; 5.2.4 Chalcones; 5.2.5 Isoflavonoids; 5.2.6 Catechins; 5.2.7 Xanthones; 5.3 Chromones; 5.4 Phenolic Acids and Tannins; 5.4.1 Phenol Acids; 5.4.2 Tannins; 5.4.3 Simple Phenol Derivatives and Polyphenols; 5.5 Stilbenes and Derivatives; 5.6 Coumarins 5.7 Benzoquinones and Anthraquinones5.8 Alkaloids; 5.9 Terpenes; 5.10 Lignans; 5.11 Fatty Acid; 5.12 Saccharides, Peptides and Amino Acid Derivatives; 5.13 BACE1 Inhibitory Active Extracts of Natural Products; 5.14 Bioassays for the Discovery of BACE1 Inhibitors; 5.15 Prospective; Acknowledgements; References; Chapter 6 Hypoglycaemic Effects of Plants Food Constituents via Inhibition of Carbohydrate-Hydrolysing Enzymes: From Chemistry to Future Applications; 6.1 Introduction; 6.2 a-Amylase; 6.3 a-Glucosidase; 6.4 Hypoglycaemic Natural Compounds; 6.4.1 Flavonoids; 6.4.2 Phenolic Acids Cover; Title Page; Copyright; Contents; List of Contributors; Chapter 1 Natural Products as Enzyme Inhibitors; 1.1 Why Are Natural Products Good Enzyme Inhibitors?; 1.2 Drawbacks of Natural Products; 1.3 The Future of Natural Products Drug Discovery; 1.3.1 New Sources and New Production Methods; 1.3.2 New Strategies for Delivery; 1.3.3 New Targets?/Drug Repurposing; 1.4 Conclusion; References; Chapter 2 Molecular Targets of Clinically Relevant Natural Products from Filamentous Marine Cyanobacteria; 2.1 Introduction; 2.2 Histone Deacetylase Inhibitors; 2.2.1 Largazole; 2.2.2 Santacruzamate A Chapter 3 Natural Angiotensin Converting Enzyme (ACE) Inhibitors with Antihypertensive Properties3.1 Introduction; 3.2 Mechanisms of Blood Pressure Regulation; 3.2.1 Renin-Angiotensin-Aldosterone System; 3.3 The Treatment of Hypertension; 3.3.1 Angiotensin Converting Enzyme Inhibitors; 3.4 Natural Products as Angiotensin Converting Enzyme Inhibitors; 3.4.1 Polyphenols; 3.4.2 Protein Derived Peptides; 3.5 Conclusions; References; Chapter 4 Phospholipase A2 Inhibitors of Marine Origin; 4.1 Relevance of Marine Organisms; 4.2 Inflammation; 4.2.1 Phospholipase A2
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
9783527805938 3527805931 9783527805921 3527805923
Enzymes--Effect of drugs on. Natural products--Therapeutic use. Bioactive compounds. MEDICAL / Physiology. SCIENCE / Life Sciences / Human Anatomy & Physiology. Bioactive compounds. Enzymes--Effect of drugs on. Natural products--Therapeutic use.