TY  - BOOK
AU  - Huang,Peiqiang
AU  - Yao,Zhu-Jun
AU  - Hsung,Richard P.
TI  - Efficiency in natural product total synthesis
SN  - 9781118940228
AV  - QD415 
U1  - 547/.2 23
PY  - 2018///
CY  - Hoboken, NJ
PB  - John Wiley & Sons
KW  - Natural products
KW  - Synthesis
KW  - Organic compounds
KW  - SCIENCE / Chemistry / Organic
KW  - bisacsh
KW  - fast
KW  - Electronic books
N1  - Includes bibliographical references and index; Intro; Title Page; Copyright Page; Contents; Contributors; Foreword; Preface; Introduction; 1 The Golden Age of the Total Synthesis of Natural Products: The Era as a Dominant Field; 2 1991-2000: A Contrasting Decade; 3 Total Synthesis in the Twenty-First Century; 4 The Challenges of the Efficiency in the Total Synthesis of Natural Products; 5 The Renaissance of Natural Products as Drug Candidates; 6 Recent Recognition of the Contribution of Natural Product-Based Drugs to Society; Acknowledgements; References; Chapter 1 Principles for Synthetic Efficiency and Expansion of the Field; 1.1 Concepts for Efficiency in the Total Synthesis of Natural Products1.1.1 Ideal Synthesis; 1.1.2 Selectivity; 1.1.3 Green Synthesis; 1.1.4 Atom Economy; 1.1.5 E Factors; 1.1.6 Step Economy; 1.1.7 Pot Economy and PASE (Pot, Atom, and Step Economy); 1.1.8 Redox Economy; 1.1.9 Protecting-Group-Free Synthesis; 1.1.10 Multicomponent Reactions and One-Pot Reactions; 1.1.11 Scalability; 1.1.12 Convergent Synthesis; 1.2 Biomimetic Synthesis; 1.2.1 Basic Logic of Biosynthesis; 1.2.2 Tandem, Cascade, and Domino Reactions -- One-Pot Reactions; 1.2.3 Site and Stereoselective Reactions; Chapter 2 Selected Procedure-Economical Enantioselective Total Syntheses of Natural Products2.1 One-Step/One-Pot Enantioselective Total Synthesis of Natural Products/Drugs; 2.1.1 Robinson's One-Step Synthesis of Tropinone; 2.1.2 Hayashi's One-Pot Synthesis of (+)-ABT-341; 2.2 Two-Step/Two-Pot Enantioselective Total Synthesis of Natural Products; 2.2.1 Hayashi's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.2 Ma's Two-Pot Synthesis of (−)-Oseltamivir; 2.2.3 Li's Two-Step Chemoenzymatic Total Synthesis of Aszonalenin; 2.2.4 Ishikawa's Two-Step Total Syntheses of (+)-WIN 64821 and (+)-Naseseazine B; 2.3 Three-Step/Three-Pot Enantioselective Total Synthesis of Natural Products2.3.1 Carreira's Three-Step Asymmetric Total Syntheses of (+)-Aszonalenin and (−)-Brevicompanine B; 2.3.2 Husson's Three-Step Asymmetric Total Synthesis of (−)-Sibirine; 2.3.3 MacMillan's Three-Step Asymmetric Total Synthesis of (+)-Frondosin B; 2.3.4 Hayashi's Three-Pot Total Synthesis of (−)-PGE1 Methyl Ester; 2.3.5 Porco's Three-Pot Total Synthesis of (−)-Hyperibone K; 2.4 Four-Step Enantioselective Total Synthesis of Natural Products; 2.4.1 Lawrence's Four-Step Total Synthesis of (−)-Angiopterlactone A
UR  - https://doi.org/10.1002/9781118940228
ER  -