Drug selectivity : an evolving concept in medicinal chemistry / edited by Norbert Handler and Helmut Buschmann.
Material type: TextSeries: Methods and principles in medicinal chemistry ; v. 72.Publisher: Weinheim, Germany : Wiley-VCH, [2018]Copyright date: ©2018Description: 1 online resourceContent type:- text
- computer
- online resource
- 9783527674411
- 3527674411
- 9783527674381
- 3527674381
- 615.1 23
- RM300
- W1
- QV 745
Introduction. Polypharmacology in Drug Discovery / Oscar Méndez-Lucio, J Jesús Naveja, Hugo Vite-Caritino, Fernando D Prieto-Martínez, José L Medina-Franco -- Selectivity of Marketed Drugs. Kinase Inhibitors / Peng Wu, Michael Givskov, Thomas E Nielsen -- Repositioning of Drug -- New Indications for Marketed Drugs / Ren Kong, Stephen T Wong -- Discovery Technologies for Drug Repurposing / Naiem T Issa, Stephen W Byers, Sivanesan Dakshanamurthy -- Unselective Drugs in Drug Discovery. Personalized Medicine / Christian Noe, Volker Baumann -- Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases / Annachiara Gandini, Federica Prati, Elisa Uliassi, Maria L Bolognesi -- Designing Approaches to Multitarget Drugs / Luca Costantino, Daniela Barlocco -- The Linker Approach / Daniel Merk, Manfred Schubert-Zsilavecz -- Merged Multiple Ligands / Hongming Chen, Udo Bauer, Ola Engkvist -- Pharmacophore Generation for Multiple Ligands / Norbert Handler -- Cellular Assays / Ye Fang -- Therapeutic Areas for Designed Multiple Ligands. Developing Serotonergic Antidepressants Acting on More Than the Serotonin Transporter / Gerard J Marek -- Multiple Ligands Targeting the Angiotensin System for Hypertension / Agustin Casimiro-Garcia -- Multiple Peroxisome Proliferator-Activated Receptor-Based Ligands / Dmytro Kukhtar, Miquel Mulero, Raul Beltrán-Debón, Cristina Valls, Gerard Pujadas, Santiago Garcia-Vallve -- Antibiotics / Jean-Philippe Surivet, Philippe Panchaud -- Multiple Ligands in Neurodegenerative Diseases / Julien Lalut, Christophe Rochais, Patrick Dallemagne.
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